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Current >> Index >> Plenary Speakers
Dr.Michael H. Kogut
USDA-ARS
USA
Title: Interactive Network between Nutrition,Immunity,the Gut Microbiota and Poultry Health

 

 

Summary:
Understanding how the diet and nutritional status influence poultry health has been a long standing area of scientific research. The established perception that host defense and nutritional status impact each other must now be expanded to include a third component of this network: the gut microbiota. This biological ménage a trois is a multi-faceted relationship that can no longer be considered exclusively dependent on the host, but is also dependent on a second genomic component within the host, the microbiome. There is solid evidence that the microbiome programs host immunity and drives a metabolome that impacts micronutrients and energy balance. In turn, the host immunity shapes the microbiome and host nutritional status influences elements of host defenses and make-up of commensal microbial community.

Biography:
Dr. Kogut is a Research Microbiologist and Lead Scientist within the Food and Feed Safety research Unit at the Southern Plains Agricultural Research Center, College station, TX, USA.

Dr. Kogut’s research is centered on alternatives to antibiotics to control disease and increase production; specifically the development of cost-effective, pre-harvest immunological interventions to improve gut health by studying:

• Role of the microbiota in immunity to infection
• Role of dietary metabolites in promoting immune regulation and immune responses to pathogens
• Tissue specific regulatory responses to infection
• Characterizing novel molecular targets that mediate the actions of dietary compounds and botanicals in inflammation and immunity
• Investigating how diet modulates the gut microbiome and mucosal immune responses

Further, metabolism and host immunity are essential requirements for survival.  Mounting an immune response requires major changes to metabolic processes.  Thus, the integration of central metabolic pathways and nutrient sensing with antibacterial immunity alters cellular energy homeostasis and contributes to the prevention or resolution of infectious diseases.  Hence, immune and metabolic response processes govern infection diseases.  A greater understanding of the critical nodes of immunometabolism during Salmonella and Campylobacter infections will provide opportunities to break the tight connection of defects in metabolism and immunity that propagate persistent infections resulting in improved safety of food products without the use of antibiotics.
 

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